Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft
tissue. Although this pathological osteogenesis process involves the participation of …

Hedgehog (Hh) signaling has been widely acknowledged to play essential roles in many
developmental processes, including endochondral ossification and growth plate …

A common stage of advanced prostate cancer is castration-resistant prostate cancer
(CRPC), greater understanding of which is required in order to address and solve the …

The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae.
Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs …

Cathepsins play a role in regulation of cell function through their presence in the cell
nucleus. However, the role of Cathepsin K (Ctsk) as an epigenetic regulator in osteoclasts …

Introduction. Regeneration of fibrochondrocytes is essential for the healing of the tendon‐
bone interface (TBI), which is similar to the formation of neurogenic heterotopic ossification …

Imbalance of bone homeostasis induces bone degenerative diseases such as osteoporosis.
Hedgehog (Hh) signaling plays critical roles in regulating the development of limb and joint …

Tendinopathy is a common disorder that leads to pain and impaired quality of life. Recent
studies revealed that osteogenic differentiation of tendon stem/progenitor cells (TSPCs) …

Tendon is a bradytrophic and hypovascular tissue, hence, healing remains a major
challenge. The molecular key events involved in successful repair have to be unravelled to …

Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant
health and economic burden. Stem cell therapy has brought hope for tendon healing in …