Plumbing mysterious RNAs in “dark genome” for the conquest of human diseases
LA Huang, C Lin, L Yang - Molecular Therapy, 2023 - cell.com
Next-generation sequencing has revealed that less than 2% of transcribed genes are
translated into proteins, with a large portion transcribed into noncoding RNAs (ncRNAs) …
translated into proteins, with a large portion transcribed into noncoding RNAs (ncRNAs) …
Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis
J Scholda, TTA Nguyen, F Kopp - Human Genetics, 2023 - Springer
Normal cell and body functions need to be maintained and protected against endogenous
and exogenous stress conditions. Different cellular stress response pathways have evolved …
and exogenous stress conditions. Different cellular stress response pathways have evolved …
Context-dependent function of long noncoding RNA PURPL in transcriptome regulation during p53 activation
CCR Hartford, RL Shrestha, L Pongor… - … and Cellular Biology, 2022 - Am Soc Microbiol
ABSTRACT PURPL is a p53-induced lncRNA that suppresses basal p53 levels. Here, we
investigated PURPL upon p53 activation in liver cancer cells, where it is expressed at …
investigated PURPL upon p53 activation in liver cancer cells, where it is expressed at …
A circular RNA from the MDM2 locus controls cell cycle progression by suppressing p53 levels
R Chaudhary, BR Muys, I Grammatikakis… - … and cellular biology, 2020 - Am Soc Microbiol
Circular RNAs (circRNAs) are a class of noncoding RNAs produced by a noncanonical form
of alternative splicing called back-splicing. To investigate a potential role of circRNAs in the …
of alternative splicing called back-splicing. To investigate a potential role of circRNAs in the …
Genome-wide analysis of the FOXA1 transcriptional network identifies novel protein-coding and long noncoding RNA targets in colorectal cancer cells
SB Lazar, L Pongor, XL Li, I Grammatikakis… - … and Cellular Biology, 2020 - Taylor & Francis
Differentiation status of tumors is correlated with metastatic potential and malignancy.
FOXA1 (forkhead box A1) is a transcription factor known to regulate differentiation in certain …
FOXA1 (forkhead box A1) is a transcription factor known to regulate differentiation in certain …
KDM6A-mediated expression of the long noncoding RNA DINO causes TP53 tumor suppressor stabilization in human papillomavirus 16 E7-expressing cells
ABSTRACT Human papillomavirus 16 (HPV16) E7 has long been known to stabilize the
tumor suppressor TP53. However, the molecular mechanism of TP53 stabilization by HPV16 …
tumor suppressor TP53. However, the molecular mechanism of TP53 stabilization by HPV16 …
Sample-Wise and Gene-Wise Comparisons Confirm a Greater Similarity of RNA and Protein Expression Data at the Level of Molecular Pathways and Suggest an …
M Raevskiy, M Sorokin, A Emelianova… - Biochemistry …, 2024 - Springer
Identification of genes and molecular pathways with congruent profiles in the proteomic and
transcriptomic datasets may result in the discovery of promising transcriptomic biomarkers …
transcriptomic datasets may result in the discovery of promising transcriptomic biomarkers …
Efficient Development of Platform Cell Lines Using CRISPR-Cas9 and Transcriptomics Analysis
ATJ Kwon, K Mohri, S Takizawa, T Arakawa… - bioRxiv, 2020 - biorxiv.org
Antibody-drug conjugates offers many advantages as a drug delivery platform that allows for
highly specific targeting of cell types and genes. Ideally, testing the efficacy of these systems …
highly specific targeting of cell types and genes. Ideally, testing the efficacy of these systems …