Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

The amyloid β-protein (Aβ) is subject to proteolytic degradation by a diverse array of
peptidases and proteinases, known collectively as Aβ-degrading proteases (AβDPs). A …

Neurodegenerative disorders involve the slow and gradual degeneration of axons and
neurons in the central nervous system (CNS), resulting in abnormalities in cellular function …

Parkinsonism is a progressive motor disease that affects 1.5 million Americans and is the
second most common neurodegenerative disease after Alzheimer's. Typical …

The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

Parkinson's disease is the second most common neurodegenerative movement disorder;
however, its etiology remains elusive. Nevertheless, in vivo observations have concluded …

Converging research efforts suggest that nicotine and other drugs that act at nicotinic
acetylcholine receptors (nAChRs) may be beneficial in the management of Parkinson's …

Parkinson's disease (PD) as a prevalent neurodegenerative condition impairs motor function
and is caused by the progressive deterioration of nigrostriatal dopaminergic (DAergic) …

Parkinson's disease is a debilitating movement disorder characterized by a generalized
dysfunction of the nervous system, with a particularly prominent decline in the nigrostriatal …

Context: Parkinson's disease (PD) is the second common progressive neurodegenerative
disease, distressing older men and is prevalent Worldwide. Objectives: This article is aimed …