Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Importance Patients with advanced soft tissue sarcoma (STS) have a median overall survival
of less than 2 years. In a phase 2 study, an overall survival benefit in this population was …

Background Sarcomas exhibit low expression of factors related to immune response, which
could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into …

Simple Summary Solitary fibrous tumor (SFT) is a malignant condition that exhibits different
clinical behaviors ranging from low to high aggressive SFT, with dedifferentiated SFT (DD …

Background Metastatic leiomyosarcomas have a poor prognosis, and currently doxorubicin
alone is used as the standard first-line treatment. Doxorubicin combined with trabectedin …

Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

Uterine leiomyosarcoma is the most common type of uterine sarcoma. It is an extremely
aggressive malignancy associated with a poor overall prognosis. Women affected may vary …

Recent advances in materials science and engineering highlight the importance of
designing sophisticated biomaterials with well-defined architectures and tunable properties …