Increasing evidence has highlighted the critical role of early life environment in shaping the
future health outcomes of an individual. Moreover, recent studies have revealed that early …

The prevalence of obesity and type 2 diabetes mellitus epidemics presents a great health
problem worldwide. Beside the changes in diet and decreased physical activity, there is …

Humans are chronically exposed to multiple exogenous substances, including
environmental pollutants, drugs and dietary components. Many of these compounds are …

Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-
disrupting chemicals (EDCs). A vast body of literature links exposure to these chemicals with …

Primary liver cancer has the sixth highest incidence and fourth highest cancer mortality
worldwide. Hepatitis B is the leading cause of liver cancer, though its incidence is …

Liver cancer is the second leading worldwide cause of cancer‑associated mortalities.
Hepatocellular carcinoma, which accounts for the majority of liver tumors, ranks fifth among …

Arrival of multi-colored fluorescent proteins and advances in live cell imaging has
immensely contributed to our understanding of intracellular trafficking of nuclear receptors …

Endocrine-disrupting chemicals (EDCs) are exogenous substances interfering with hormone
biosynthesis, metabolism, or action, and consequently causing disturbances in the …

Pregnane xenobiotic receptor (PXR) is an orphan nuclear receptor that regulates the
metabolism of endobiotics and xenobiotics. PXR is promiscuous and unique in that it is …

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk
factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic …