Protein tyrosine kinases (PTKs) are a class of proteins with tyrosine kinase activity that
phosphorylate tyrosine residues of critical molecules in signaling pathways. Their basal …

There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to
originate from undifferentiated neural crest cells. Amplification of the MYC family member …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes. To better
understand neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome …

Genetic studies have established anaplastic lymphoma kinase (ALK), a cell surface receptor
tyrosine kinase, as a tractable molecular target in neuroblastoma. We describe …

Neuroblastoma (NB), the most common extracranial tumor of childhood, is a cancer of
primordial neural crest cells that give rise to sympathetic neural ganglia and adrenal …

Selection of the best tumor antigen is critical for the therapeutic success of chimeric antigen
receptor (CAR) T cells in hematologic malignancies and solid tumors. The anaplastic …

Anaplastic lymphoma kinase (ALK) activation has been associated with many types of
human cancer. Significant efforts have been devoted to the development of ALK inhibitors to …