Hypotensive snake venom components—a mini-review
Hypertension is considered a major public health issue due to its high prevalence and
subsequent risk of cardiovascular and kidney diseases. Thus, the search for new …
subsequent risk of cardiovascular and kidney diseases. Thus, the search for new …
Snake venom components: tools and cures to target cardiovascular diseases
Cardiovascular diseases (CVDs) are considered as a major cause of death worldwide.
Therefore, identifying and developing therapeutic strategies to treat and reduce the …
Therefore, identifying and developing therapeutic strategies to treat and reduce the …
Modulation of mouse embryonic stem cell proliferation and neural differentiation by the P2X7 receptor
Background Novel developmental functions have been attributed to the P2X7 receptor
(P2X7R) including proliferation stimulation and neural differentiation. Mouse embryonic …
(P2X7R) including proliferation stimulation and neural differentiation. Mouse embryonic …
Nature-derived peptides: a growing niche for GPCR ligand discovery
G protein-coupled receptors (GPCRs) represent important drug targets, as they regulate
pivotal physiological processes and they have proved to be readily druggable. Natural …
pivotal physiological processes and they have proved to be readily druggable. Natural …
ATP and spontaneous calcium oscillations control neural stem cell fate determination in Huntington's disease: a novel approach for cell clock research
T Glaser, H Shimojo, DE Ribeiro, PPL Martins… - Molecular …, 2021 - nature.com
Calcium, the most versatile second messenger, regulates essential biology including crucial
cellular events in embryogenesis. We investigated impacts of calcium channels and …
cellular events in embryogenesis. We investigated impacts of calcium channels and …
Proline rich-oligopeptides: Diverse mechanisms for antihypertensive action
KLP Morais, D Ianzer, JRR Miranda, RL Melo… - Peptides, 2013 - Elsevier
Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s,
were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides …
were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides …
[HTML][HTML] Bj-PRO-5a, a natural angiotensin-converting enzyme inhibitor, promotes vasodilatation mediated by both bradykinin B2 and M1 muscarinic acetylcholine …
Bradykinin-potentiating peptides (BPPs) or proline-rich oligopeptides (PROs) isolated from
the venom glands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin …
the venom glands of Bothrops jararaca (Bj) were the first natural inhibitors of the angiotensin …
Snake venom toxins targeting the central nervous system
A Talukdar, P Maddhesiya, ND Namsa, R Doley - Toxin Reviews, 2023 - Taylor & Francis
Snake venom is a blend of bioactive proteins, polypeptides, and various other substances
with toxic and lethal properties that are known to modulate varied physiological and …
with toxic and lethal properties that are known to modulate varied physiological and …
[HTML][HTML] Protective effects of distinct proline-rich oligopeptides from B. jararaca snake venom against oxidative stress-induced neurotoxicity
SM Querobino, MS Costa, C Alberto-Silva - Toxicon, 2019 - Elsevier
The low molecular mass fraction from Bothrops jararaca snake venom contains proline-rich
peptides (Bj-PROs), also known as bradykinin-potentiating peptides (BPPs), which were …
peptides (Bj-PROs), also known as bradykinin-potentiating peptides (BPPs), which were …