[HTML][HTML] Advancing application of mesenchymal stem cell-based bone tissue regeneration

F Shang, Y Yu, S Liu, L Ming, Y Zhang, Z Zhou, J Zhao… - Bioactive materials, 2021 - Elsevier
Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Melatonin and calcium function synergistically to promote the resilience through ROS metabolism under arsenic-induced stress

MH Siddiqui, S Alamri, MN Khan, FJ Corpas… - Journal of Hazardous …, 2020 - Elsevier
The interplay between melatonin (Mel) and calcium (Ca 2+) in enhancing tolerance to
metalloid toxicity and underlying physiological and biochemical mechanisms of this …

Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

KB Juybari, MH Pourhanifeh, A Hosseinzadeh… - Virus research, 2020 - Elsevier
Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …

[HTML][HTML] Melatonin for the prevention and treatment of cancer

Y Li, S Li, Y Zhou, X Meng, JJ Zhang, DP Xu, HB Li - Oncotarget, 2017 - ncbi.nlm.nih.gov
The epidemiological studies have indicated a possible oncostatic property of melatonin on
different types of tumors. Besides, experimental studies have documented that melatonin …

Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

I Buendia, P Michalska, E Navarro, I Gameiro… - Pharmacology & …, 2016 - Elsevier
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Extrapineal melatonin: sources, regulation, and potential functions

D Acuña-Castroviejo, G Escames, C Venegas… - Cellular and molecular …, 2014 - Springer
Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

HM Zhang, Y Zhang - Journal of pineal research, 2014 - Wiley Online Library
Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Oxidative stress and BPA toxicity: an antioxidant approach for male and female reproductive dysfunction

R Meli, A Monnolo, C Annunziata, C Pirozzi… - Antioxidants, 2020 - mdpi.com
Bisphenol A (BPA) is a non-persistent anthropic and environmentally ubiquitous compound
widely employed and detected in many consumer products and food items; thus, human …

Melatonin—A pleiotropic, orchestrating regulator molecule

R Hardeland, DP Cardinali, V Srinivasan… - Progress in …, 2011 - Elsevier
Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …