Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - Elsevier
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Dopamine in health and disease: much more than a neurotransmitter

R Franco, I Reyes-Resina, G Navarro - Biomedicines, 2021 - mdpi.com
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through
the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher …

Anti‐inflammatory and immune‐modulatory impacts of berberine on activation of autoreactive T cells in autoimmune inflammation

SM Ehteshamfar, M Akhbari, JT Afshari… - Journal of cellular …, 2020 - Wiley Online Library
Autoreactive inflammatory CD4+ T cells, such as T helper (Th) 1 and Th17 subtypes, have
been found to associate with the pathogenesis of autoimmune disorders. On the other hand …

Metabolomics reveals metabolic biomarkers of Crohn's disease

J Jansson, B Willing, M Lucio, A Fekete, J Dicksved… - PloS one, 2009 - journals.plos.org
The causes and etiology of Crohn's disease (CD) are currently unknown although both host
genetics and environmental factors play a role. Here we used non-targeted metabolic …

Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in …

M Levite - Acta physiologica, 2016 - Wiley Online Library
Dopamine, a principal neurotransmitter, deserves upgrading to 'NeuroImmunotransmitter'
thanks to its multiple, direct and powerful effects on most/all immune cells. Dopamine by …

T-cell-driven inflammation as a mediator of the gut-brain axis involved in Parkinson's disease

J Campos-Acuña, D Elgueta, R Pacheco - Frontiers in immunology, 2019 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder affecting mainly the dopaminergic
neurons of the nigrostriatal pathway, a neuronal circuit involved in the control of movements …

The dopaminergic system in autoimmune diseases

R Pacheco, F Contreras, M Zouali - Frontiers in immunology, 2014 - frontiersin.org
Bidirectional interactions between the immune and the nervous systems are of considerable
interest both for deciphering their functioning and for designing novel therapeutic strategies …

[HTML][HTML] Dopamine, a co-regulatory component, bridges the central nervous system and the immune system

M Li, L Zhou, X Sun, Y Yang, C Zhang, T Wang… - Biomedicine & …, 2022 - Elsevier
Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining
physiological function in human body. In the past, most studies focused on the relationship …

[HTML][HTML] Dopamine and renal function and blood pressure regulation

I Armando, MV Van Anthony… - Comprehensive Physiology, 2011 - ncbi.nlm.nih.gov
Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It
affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion …

Targeting the dopaminergic system in autoimmunity

PM Vidal, R Pacheco - Journal of Neuroimmune Pharmacology, 2020 - Springer
Dopamine has emerged as a fundamental regulator of inflammation. In this regard, it has
been shown that dopaminergic signalling pathways are key players promoting homeostasis …