Cancer cells consume glutamine, a nonessential amino acid (NEAA), at exceedingly high
rates to fulfill their energetic and biosynthetic requirements for proliferation. Glutamine plays …

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline
axis is an important node of cancer metabolism and plays a major role in amino acid …

During G 1-phase of the cell cycle, normal cells respond first to growth factors that indicate
that it is appropriate to divide and then later in G 1 to the presence of nutrients that indicate …

Introduction Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been
shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies …

Background SIRT4, a protein localized in the mitochondria, is one of the least characteristic
members of the sirtuin family. It is known that SIRT4 has deacetylase activity and plays a role …

The role of PI3K/AKT/mTOR signalling pathway has been widely deciphered in
pathogenesis of epilepsy. LY294002 is a selective inhibitor of phosphatidylinositol-3-kinase …

Abstract Changes in metabolism are common phenomena in tumors. Glutamine (Gln) has
been documented to play a critical role in tumor growth. In this study, we aimed to to explore …

Oncogenic KRas mutations are present in about 30% of all human cancers and in more than
90% of pancreatic cancers. KRas-driven cancers have been largely resistant to therapeutic …

It has become clearer that advanced cancer, especially advanced breast cancer, is an
entirely displayed pathological system that is much more complex than previously …

mTOR–the mammalian/mechanistic target of rapamycin–has been implicated as a key
signaling node for promoting survival of cancer cells. However, clinical trials that have …