Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …

Background.—Under the auspices of the College of American Pathologists, the current state
of knowledge regarding pathologic prognostic factors (factors linked to outcome) and …

Excessive incidence of various cancers is a challenging feature of the hereditary‐non‐
polyposis‐colorectal‐cancer (HNPCC) syndrome. This study estimated the cancer …

Abstract BACKGROUND The American Joint Committee on Cancer (AJCC), which regularly
reviews TNM staging systems, established a working party to develop recommendations for …

Familial colorectal cancer (CRC) is a major public health problem by virtue of its relatively
high frequency. Some 15-20% of all CRCs are familial. Among these, familial adenomatous …

Cancer with high levels of microsatellite instability (MSI-H) is the hallmark of hereditary
nonpolyposis colorectal cancer syndrome, and MSI-H occurs in∼ 15% of sporadic …

Background & Aims: The revised Bethesda guidelines for Lynch syndrome recommend
microsatellite instability (MSI) testing all colorectal cancers in patients diagnosed before age …