Although the majority of annotated new genes in a given genome appear to have arisen
from duplication-related mechanisms, recent studies have shown that genes can also …

Abstract OrthoDB (https://www. orthodb. org) offers evolutionary and functional annotations
of orthologous genes in the widest sampling of eukaryotes, prokaryotes, and viruses …

Interactions between thousands of proteins define cells' protein–protein interaction (PPI)
network. Some of these interactions lead to the formation of protein complexes. It is …

Differential gene transcription enables development and homeostasis in all animals and is
regulated by two major classes of distal cis-regulatory DNA elements (CREs): enhancers …

Mutating replication-dependent (RD) histone genes is an important tool for understanding
chromatin-based epigenetic regulation. Deploying this tool in metazoans is particularly …

Abstract The Complex Portal (www. ebi. ac. uk/complexportal) is a manually curated
reference database for molecular complexes. It is a unifying web resource linking …

Diverse eukaryotic cells assemble microtubule networks that vary in structure and
composition. While we understand how cells build microtubule networks with specialized …

Sand flies infect more than 1 million people annually with Leishmania parasites and other
bacterial and viral pathogens. Progress in understanding sand fly adaptations to xenobiotics …

Ubiquitin controls many cellular processes via its posttranslational conjugation onto
substrates. Its use is highly variable due to its ability to form poly-ubiquitin chains with …

Astrocytes help protect neurons from potential damage caused by reactive oxygen species
(ROS). While ROS can also exert beneficial effects, it remains unknown how neuronal ROS …