Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Polyamines are essential for the growth and proliferation of mammalian cells and are
intimately involved in biological mechanisms such as DNA replication, RNA transcription …

Abstract mRNA delivery has shown high application value in the treatment of various
diseases, but its effective delivery is still a major challenge at present. Herein, we propose a …

The eukaryotic translation initiation factor 5A (eIF5A) is an evolutionarily conserved protein
that binds ribosomes to facilitate the translation of peptide motifs with consecutive prolines or …

Background Basal-like breast cancer (BLBC) is the most aggressive subtype of breast
cancer due to its aggressive characteristics and lack of effective therapeutics. However, the …

We synthesized new aroyl diheterocyclic pyrrole (ARDHEP) 15 that exhibited the hallmarks
of ferroptosis. Compound 15 strongly inhibited U-87 MG, OVCAR-3, and MCF-7 cancer cells …

In tumourigenesis, oncogenes or dysregulated tumour suppressor genes alter the canonical
translation machinery leading to a reprogramming of the translatome that, in turn, promotes …

A key mechanism driving colorectal cancer (CRC) development is the upregulation of MYC
and its targets, including ornithine decarboxylase (ODC), a master regulator of polyamine …

Colorectal cancer (CRC) is a malignant tumor initiating from the mucosa of the colorectum.
According to the 2020 statistics from the World Health Organization, there are 10.0% CRC …

Background BRAF inhibitors are widely employed in the treatment of melanoma with the
BRAF V600E mutation. However, the development of resistance compromises their …