The prevalence of diabetes mellitus is on the rise, which demands the identification of novel
antidiabetic drugs. There is a need for safer and more effective alternatives because the …

In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …

thiazolidinedione-phenothiazine molecular hybrids, 9a–9t were synthesized, characterized
and screened for antidiabetic activities viz., α-amylase inhibition and glucose uptake assay …

In pursuit of novel antidiabetic agents to combat type II diabetes mellitus, our study focused
on identifying pharmacophoric features responsible for PPAR-γ expression, a key regulator …

Treatments to combat giardiasis have been reported to have several drawbacks, partly due
to the drug resistance and toxicity of current antiparasitic agents. These constraints have …

Abstract Design, synthesis, and biological evaluation of two series of O 4′-benzyl-hispidol
derivatives and the analogous corresponding O 3′-benzyl derivatives aiming to develop …

Herein, we describe the structure-based designing and synthesis of novel glitazones with
imidazolidine 2, 4‑dione and 2-thioxo thiazolidine-4-one ring structures as the fundamental …

Type 2 diabetes mellitus is a bipolar metabolic disorder characterized by abnormalities in
insulin production from β-cells and insulin resistance. Thiazolidinediones are potent anti …

En este trabajo se preparó una serie de diez 4-ariloxi-5-bencilidenobarbituratos e
hidantoínas como bioisósteros de la 1, 3-tiazolidina-2, 4-diona. Se realizó un análisis de …

Derivatives combining acridine, pyrrole, and thiazolidine rings have emerged as promising
candidates in the field of antitumor drug discovery. This paper aims to highlight the …