Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

The applicability of computational models to the biological world is an active topic of debate.
We argue that a useful path forward results from abandoning hard boundaries between …

Many aspects of health and disease are modeled using the abstraction of a" pathway"—a
set of protein or other subcellular activities with specified functional linkages between them …

Gene regulatory networks (GRNs) process important information in developmental biology
and biomedicine. A key knowledge gap concerns how their responses change over time …

Aging is a complex biological process, which determines the life span of an organism.
Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging …

A well‐known hypothesis, with far‐reaching implications, is that biological evolution should
preferentially lead to states that are dynamically critical. In previous papers, we showed that …

Hematopoietic stem cells (HSCs) provide all types of blood cells during the entire life of the
organism. HSCs are mainly quiescent and can eventually enter the cell cycle to differentiate …

It took quite a long time to complete this book. More than 20 years had elapsed since I wrote
my last volume as an author, not just as an editor. And I felt it important to find again the …

Design and implementation of robust network modules is essential for construction of
complex biological systems through hierarchical assembly of 'parts' and 'devices'. The …