Alterations in ocular blood flow have been identified as important risk factors for the onset
and progression of numerous diseases of the eye. In particular, several population-based …

The microcirculation plays a major role in maintaining homeostasis in the body. Alterations
or dysfunctions of the microcirculation can lead to several types of serious diseases. It is not …

We developed a mathematical model to characterize how macular oxygenation may be
affected by abnormalities in the retinal and choroidal oxygen supplies. The macular region is …

Glaucoma is a multi-factorial ocular disease associated with death of retinal ganglion cells
and irreversible vision loss. Many risk factors contribute to glaucomatous damage, including …

Mathematical models linking ocular mechanics, circulation, and oxygenation are needed to
improve the interpretation and prediction of key components of ocular health and disease …

Introduction: Reduction of intraocular pressure, the only currently approved therapy for Open-
angle glaucoma (OAG), has yet to fully arrest the disease process in many individuals …

Purpose: This study uses a theoretical model to investigate the response of retinal blood
flow to changes in tissue oxygen demand. The study is motivated by the need for a better …

The hemodynamic conditions and partial pressure of oxygen in microcirculation generally
indicate the status of tissue perfusion, which provides essential information for the …