Many proteins in living organisms are glycosylated. As their glycan patterns exhibit protein‐,
cell‐, and tissue‐specific heterogeneity, changes in the glycosylation levels could serve as …

Simple Summary Stem cells represent hope for millions of patients seeking prompt recovery.
Unfortunately, the process of converting stem cells into the target cells that will replace the …

The application of stem-cell-based therapies in regenerative medicine is hindered by the
tumorigenic potential of residual human pluripotent stem cells. Previously, we identified a …

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all cancers. To
improve PDAC therapy, we establish screening systems based on organoid and co-culture …

Single-cell sequencing has emerged as an indispensable technology to dissect cellular
heterogeneity but never been applied to the simultaneous analysis of glycan and RNA …

Lectins are carbohydrate binding proteins present in seeds of many plants, especially corals
and beans, in fungi and bacteria, and in animals. Apart from their hemagglutinating property …

The detailed mechanism of reprogramming somatic cells into induced pluripotent stem cells
(iPSCs) remains largely unknown. Partially reprogrammed iPSCs are informative and useful …

During reprogramming into human induced pluripotent stem cells (iPSCs), several stem cell
marker genes are induced, such as OCT-4, NANOG, SALL4, and TERT. OCT-4, NANOG …

The therapeutic potential of mesenchymal stem cell (MSC)‐derived extracellular vesicles
(EVs) for various diseases and tissue repair is attracting attention. Here, EVs from …

Glycans are one of the major building blocks of extracellular vesicles (EVs). However, their
roles and applications have not been completely explored. Here, we analyzed the glycome …