Our understanding of human natural killer (NK) cell development lags far behind that of
human B‐or T‐cell development. Much of our recent knowledge of this incomplete picture …

The thymus is the main producer of αβ T cells and is, therefore, crucial for a normal immune
system. The intrathymic developmental pathway of human αβ T cells has now been …

Patients with relapsing-remitting multiple sclerosis (RR-MS) show a suboptimal CD4+
CD25+ regulatory T cell (Treg) function, whereas no Treg alterations are observed in …

Reconstituting the immune response will be critical for the survival of HIV-infected
individuals once viral load is brought under control. While the adult thymus was previously …

The generation of natural regulatory T cells (nTregs) is crucial for the establishment of
immunologic self-tolerance and the prevention of autoimmunity. Still, the origin of nTregs …

During development in the thymus, mature CD4+ or CD8+ cells are derived from immature
CD4+ CD8+ cells through a series of selection events. One of the hallmarks of this …

Chorioamnionitis is associated with preterm labor and fetal inflammatory response
syndrome (FIRS), causing fetal organ injury and morbidity, particularly in extremely …

Abstract CD6, a 130‐kDa surface glycoprotein, is expressed primarily on cells of T lineage.
A co‐stimulatory role for CD6 in mature T cells has been shown, but the function of CD6 …

Specialized microenvironments within the thymus are comprised of unique cell types with
distinct roles in directing the development of a diverse, functional, and self-tolerant T cell …

Ikaros is a hematopoietic cell-specific zinc finger DNA binding protein that plays an
important role in lymphocyte development. Genetic disruption of Ikaros results in T-cell …