Various technologies can be used to produce genome-scale, or'omics', data sets that
provide systems-level measurements for virtually all types of cellular components in a model …

Proteins interact with each other in a highly specific manner, and protein interactions play a
key role in many cellular processes; in particular, the distortion of protein interfaces may lead …

A variety of different social, natural and technological systems can be described by the same
mathematical framework. This holds from the Internet to food webs and to boards of …

After the completion of the human and other genome projects it emerged that the number of
genes in organisms as diverse as fruit flies, nematodes, and humans does not reflect our …

A key goal of biology is to construct networks that predict complex system behavior. We
combine multiple types of molecular data, including genotypic, expression, transcription …

Background Network concepts are increasingly used in biology and genetics. For example,
the clustering coefficient has been used to understand network architecture; the connectivity …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

The recent proliferation of protein interaction networks has motivated research into network
alignment: the cross-species comparison of conserved functional modules. Previous studies …

The tempo and mode of protein evolution have been central questions in biology. Genomic
data have shown a strong influence of the expression level of a protein on its rate of …

Biology relies on functional interplay of proteins in the crowded and heterogeneous
environment inside cells, and functional protein interactions are often weak and transient …