Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of
dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly …

Background We conducted a first-in-human dose-escalation study with the oral FASN
inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended …

The increasing incidence of obesity and its co-morbid conditions poses a great challenge to
global health. In addition to cardiovascular disease and diabetes, epidemiological data …

Introduction: Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid
synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a …

Renal cell carcinoma (RCC) is one of the most common tumours of the urinary system, and
is insidious and not susceptible to chemoradiotherapy. As the most common subtype of RCC …

Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides
an unproven approach to cancer therapy with a strong biological rationale. FASN …

A fundamental goal of epidemiologic research is to investigate the relationship between
exposures and disease risk. Cases of the disease are often considered a single outcome …

Purpose Obesity is an established risk factor for clear cell renal cell carcinoma (RCC);
however, some reports suggest that RCC developing in obese patients may be more …

Prostate cancer (PCa) metabolism appears to be unique in comparison with other types of
solid cancers. Normal prostate cells mainly rely on glucose oxidation to provide precursors …