Recent progress in understanding the molecular basis of cellular processes, identification of
promising therapeutic targets and evolution of the regulatory landscape makes this an …

Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause
of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was …

In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …

Pulmonary metastasis of breast cancer cells is promoted by a distinct population of
macrophages, metastasis-associated macrophages (MAMs), which originate from …

Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …

Macrophages, which are abundant in the tumour microenvironment, enhance malignancy.
At metastatic sites, a distinct population of metastasis-associated macrophages promotes …

Extracellular vesicles (EVs), specifically exosomes and microvesicles (MVs), are presumed
to play key roles in cell–cell communication via transfer of biomolecules between cells. The …

Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their
functional heterogeneity and origin are still largely unresolved. We report that bone marrow …

Abstract Cancer-Associated Fibroblasts (CAFs) were shown to orchestrate tumour-
promoting inflammation in multiple malignancies, including breast cancer. However, the …

We have investigated the importance of interleukin-6 (IL-6) in promoting tumor growth and
metastasis. In human primary breast cancers, increased levels of IL-6 were found at the …