Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH
from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH …

The hypothalamic decapeptide, GnRH, is the gatekeeper of mammalian reproductive
development and function. Activation of specific, high-affinity cell surface receptors (GnRH …

The activins were discovered and named based on their abilities to stimulate FSH secretion
and FSHβ (Fshb) subunit expression by pituitary gonadotrope cells. According to …

Abstract Background/Objectives: Anti-Müllerian hormone (AMH) signaling is critical for
sexual differentiation and gonadal function. AMH receptor type 2 (AMHR2) is expressed in …

The LβT2 mouse pituitary cell line has many characteristics of a mature gonadotrope and is
a widely used model system for studying the developmental processes and the response to …

L β T2 and α T3-1 are important, widely studied cell line models for the pituitary
gonadotropes that were generated by targeted tumorigenesis in transgenic mice. L β T2 …

Abstract Aflatoxin B1 (AFB1) is a fungal toxin consistently found as a contaminant in food
products such as cereals, nuts, spices, and oilseeds. AFB1 exposure can lead to …

Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses from the hypothalamus
and regulates follicle-stimulating hormone β-subunit (FSHβ) gene expression in pituitary …

The mechanisms mediating suppression of reproduction in response to decreased nutrient
availability remain undefined, with studies suggesting regulation occurs within the …

Neuroendocrine control of reproduction by brain-secreted pulses of gonadotropin-releasing
hormone (GnRH) represents a longstanding puzzle about extracellular signal decoding …