The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas
OH Petersen, JV Gerasimenko… - Physiological …, 2021 - journals.physiology.org
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …
functions of the different cell types in the exocrine pancreas as well as the roles of these …
Models of acute and chronic pancreatitis
MM Lerch, FS Gorelick - Gastroenterology, 2013 - Elsevier
Animal models of acute and chronic pancreatitis have been created to examine mechanisms
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …
of pathogenesis, test therapeutic interventions, and study the influence of inflammation on …
Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluorooctane sulfonic acid (PFOS) and …
human health related to the presence of perfluorooctane sulfonic acid (PFOS) and …
Peptide receptors as molecular targets for cancer diagnosis and therapy
JC Reubi - Endocrine reviews, 2003 - academic.oup.com
During the past decade, proof of the principle that peptide receptors can be used
successfully for in vivo targeting of human cancers has been provided. The molecular basis …
successfully for in vivo targeting of human cancers has been provided. The molecular basis …
Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion
Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …
Cholecystokinin—from local gut hormone to ubiquitous messenger
JF Rehfeld - Frontiers in endocrinology, 2017 - frontiersin.org
Cholecystokinin (CCK) was discovered in 1928 in jejunal extracts as a gallbladder
contraction factor. It was later shown to be member of a peptide family, which are all ligands …
contraction factor. It was later shown to be member of a peptide family, which are all ligands …
PPARα agonist-induced rodent tumors: modes of action and human relevance
JE Klaunig, MA Babich, KP Baetcke… - Critical reviews in …, 2003 - Taylor & Francis
Widely varied chemicals—including certain herbicides, plasticizers, drugs, and natural
products—induce peroxisome proliferation in rodent liver and other tissues. This …
products—induce peroxisome proliferation in rodent liver and other tissues. This …
Cholecystokinin and gastrin receptors
M Dufresne, C Seva, D Fourmy - Physiological reviews, 2006 - journals.physiology.org
Cholecystokinin and gastrin receptors (CCK1R and CCK2R) are G protein-coupled
receptors that have been the subject of intensive research in the last 10 years with …
receptors that have been the subject of intensive research in the last 10 years with …
The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis
RT Waldron, Y Chen, H Pham, A Go… - The Journal of …, 2019 - Wiley Online Library
Key points This work confirms previous reports that CM4620, a small molecule inhibitor of
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …
Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction …
Pancreatic cancer cachexia: three dimensions of a complex syndrome
Cancer cachexia is a multifactorial syndrome that is characterised by a loss of skeletal
muscle mass, is commonly associated with adipose tissue wasting and malaise, and …
muscle mass, is commonly associated with adipose tissue wasting and malaise, and …