Transition metal-catalysed direct borylation of hydrocarbons via C–H bond activation has
received a remarkable level of attention as a popular reaction in the synthesis of …

Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

In this review, recent examples featuring C–H functionalization in the synthesis of complex
natural products are discussed. A focus is given to the way in which C–H functionalization …

Conspectus The widespread presence of hydrocarbons makes C–H functionalization an
attractive alternative to traditional cross-coupling methods. As indole is an important …

The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Catalytic C–H oxyfunctionalization reactions have garnered significant attention in recent
years with their ability to streamline synthetic routes toward complex molecules …

Iron is an especially important redox-active cofactor in biology because of its ability to
mediate reactions with atmospheric O2. Iron-dependent oxygenases exploit this earth …

The direct functionalization of C–H bonds constitutes a powerful strategy to construct and
diversify organic molecules. However, controlling the chemo-and site-selectivity of this …

The integration of biocatalysis with chemocatalysis combines the excellent selectivity of the
former with the robust reactivity of the latter and offers many advantages, such as lower cost …

Fe (II)/α-ketoglutarate-dependent dioxygenases (α-KGDs) are widespread enzymes in
aerobic biology and serve a remarkable array of biological functions, including roles in …