Molecular host-pathogen interaction in brucellosis: current understanding and future approaches to vaccine development for mice and humans

J Ko, GA Splitter - Clinical microbiology reviews, 2003 - Am Soc Microbiol
Brucellosis caused by Brucella spp. is a major zoonotic disease. Control of brucellosis in
agricultural animals is a prerequisite for the prevention of this disease in human beings …

Biosynthesis of Vitamin B2 (Riboflavin)

A Bacher, S Eberhardt, M Fischer, K Kis… - Annual review of …, 2000 - annualreviews.org
The biosynthesis of one riboflavin molecule requires one molecule of GTP and two
molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically …

Class I. Alphaproteobacteria class. nov.

GM Garrity, JA Bell, T Lilburn - Bergey's manual® of systematic …, 2005 - Springer
Abstract Al. pha. pro. te. o. bac. te′ ri. a. Gr. n. alpha name of first letter of Greek alphabet;
Gr. n. Proteus ocean god able to change shape; Gr. n. bakterion a small rod; ML fem. pl. n …

[HTML][HTML] Brucelosis: una revisión práctica

HA Castro, SR González, MI Prat - Acta bioquímica clínica …, 2005 - SciELO Argentina
La brucelosis es una enfermedad zoonótica causada por bacterias pertenecientes al
género Brucella que ocasiona problemas de salud importantes entre los individuos que …

A DNA Vaccine Encoding Lumazine Synthase from Brucella abortus Induces Protective Immunity in BALB/c Mice

CA Velikovsky, J Cassataro… - Infection and …, 2002 - Am Soc Microbiol
This study was conducted to evaluate the immunogenicity of the Brucella abortus lumazine
synthase (BLS) gene cloned into the pcDNA3 plasmid, which is driven by the …

Brucella Lumazine Synthase Elicits a Mixed Th1-Th2 Immune Response and Reduces Infection in Mice Challenged with Brucella abortus 544 Independently of the …

CA Velikovsky, FA Goldbaum, J Cassataro… - Infection and …, 2003 - Am Soc Microbiol
The immunogenicity and protective efficacy of recombinant lumazine synthase from Brucella
spp.(rBLS) administered with different adjuvants was evaluated in mice. Mice were …

[HTML][HTML] Human infection with M-strain of Brucella canis

JC Wallach, GH Giambartolomei, PC Baldi… - Emerging infectious …, 2004 - ncbi.nlm.nih.gov
The less mucoid strain of Brucella canis or M-strain is used for the serologic diagnosis of
canine brucellosis. While this strain is avirulent in dogs, we report the case of clinical …

[图书][B] Probiotics in food safety and human health

I Goktepe, VK Juneja, M Ahmedna - 2005 - taylorfrancis.com
The discovery of new and previously unknown organisms that cause foodborne illness
makes it essential for scientists, regulators, and those in the food industry to reconsider their …

A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis …

J Cassataro, KA Pasquevich, SM Estein, DA Laplagne… - Vaccine, 2007 - Elsevier
The development of an effective subunit vaccine against brucellosis is a research area of
intense interest. The enzyme lumazine synthase from Brucella spp.(BLS) is highly …

High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase

V Zylberman, PO Craig, S Klinke, BC Braden… - Journal of Biological …, 2004 - ASBMB
The penultimate step in the pathway of riboflavin biosynthesis is catalyzed by the enzyme
lumazine synthase (LS). One of the most distinctive characteristics of this enzyme is the …