[HTML][HTML] Alveolar Macrophages in Viral Respiratory Infections: Sentinels and Saboteurs of Lung Defense
P Pöpperl, M Stoff, A Beineke - International Journal of Molecular …, 2025 - mdpi.com
Respiratory viral infections continue to cause pandemic and epidemic outbreaks in humans
and animals. Under steady-state conditions, alveolar macrophages (AlvMϕ) fulfill a …
and animals. Under steady-state conditions, alveolar macrophages (AlvMϕ) fulfill a …
[HTML][HTML] The role of alveolar macrophages in viral respiratory infections and their therapeutic implications
AP Javaherdehi, S Ghanbari, P Mahdavi… - … and Biophysics Reports, 2024 - Elsevier
Alveolar macrophages are pivotal components of the lung's innate immune defense against
respiratory virus infections. Their multifaceted role spans from viral clearance to modulation …
respiratory virus infections. Their multifaceted role spans from viral clearance to modulation …
Combination of spatial transcriptomics analysis and retrospective study reveals liver infection of SARS-COV-2 is associated with clinical outcomes of COVID-19
S Chen, Y Zhang, A Ashuo, S Song, L Yuan, W Wang… - …, 2025 - thelancet.com
Background Liver involvement is a common complication of coronavirus disease 2019
(COVID-19), especially in hospitalized patients. However, the underlying mechanisms …
(COVID-19), especially in hospitalized patients. However, the underlying mechanisms …
[HTML][HTML] RAMP1 Signaling Mitigates Acute Lung Injury by Distinctively Regulating Alveolar and Monocyte-Derived Macrophages
A Yamashita, Y Ito, M Osada, H Matsuda… - International Journal of …, 2024 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that induces
cytokine hypersecretion. Receptor activity-modifying protein (RAMP) 1, a subunit of the …
cytokine hypersecretion. Receptor activity-modifying protein (RAMP) 1, a subunit of the …
Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model
M Sasaki, T Sugi, S Iida, Y Hirata, S Kusakabe… - …, 2024 - thelancet.com
Background Pulmonary infection with SARS-CoV-2 stimulates host immune responses and
can also result in the progression of dysregulated and critical inflammation. Throughout the …
can also result in the progression of dysregulated and critical inflammation. Throughout the …
Hard CiDRE revs up macrophage infectivity in COVID-19
M Bhattacharya - Immunity, 2023 - cell.com
IL-10 has been linked to COVID-19 severity, but whether it is causal is unclear. In this issue
of Immunity, Mitsui et al. find that a specific single-nucleotide polymorphism (SNP) results in …
of Immunity, Mitsui et al. find that a specific single-nucleotide polymorphism (SNP) results in …
SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses
TP Vu Manh, C Gouin, J De Wolf, L Jouneau… - Cellular and Molecular …, 2024 - Springer
Deciphering the initial steps of SARS-CoV-2 infection, that influence COVID-19 outcomes, is
challenging because animal models do not always reproduce human biological processes …
challenging because animal models do not always reproduce human biological processes …
Necroptosis in alveolar epithelial cells drives lung inflammation and injury caused by SARS-CoV-2 infection
Y Komiya, M Kamiya, S Oba, D Kawata, H Iwai… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2 infection, results in irreversible or fatal lung
injury. We assumed that necroptosis of virus-infected alveolar epithelial cells (AEC) could …
injury. We assumed that necroptosis of virus-infected alveolar epithelial cells (AEC) could …
[HTML][HTML] Detrimental Effects of Anti-Nucleocapsid Antibodies in SARS-CoV-2 Infection, Reinfection, and the Post-Acute Sequelae of COVID-19
EE Nakayama, T Shioda - Pathogens, 2024 - mdpi.com
Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance
subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing …
subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing …
[HTML][HTML] Impact of the COVID-19 Infection on Head and Neck Cancer Treatment During Hospitalization
R Kawaura, H Shibata, H Okuda, K Terazawa… - Cureus, 2024 - ncbi.nlm.nih.gov
Objective The after-effects of coronavirus disease 2019 (COVID-19) infection are still
unknown; therefore, we investigate the possibility that COVID-19 may interrupt cancer …
unknown; therefore, we investigate the possibility that COVID-19 may interrupt cancer …