Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …

Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

Personalized medicine tailors therapies, disease prevention, and health maintenance to the
individual, with pharmacogenomics serving as a key tool to improve outcomes and prevent …

The high-order three-dimensional (3D) organization of regulatory genomic elements
provides a topological basis for gene regulation, but it remains unclear how multiple …

Summary The Central Dogma of the flow of genetic information is arguably the crowning
achievement of 20 th century molecular biology. Reversing the flow of information from RNA …

Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue
deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart …

Summary lncRNA research is passing the stage of enumerating lncRNAs or recording
simplified on-off expression switches. Mechanistic analyses are starting to reveal …

Chromatin loops (or chromatin interactions) are important elements of chromatin structures.
Disruption of chromatin loops is associated with many diseases, such as cancer and …

Identifying transcriptional enhancers and their target genes is essential for understanding
gene regulation and the impact of human genetic variation on disease 1–6. Here we create …

The clinical role of liquid biopsy in oncology is growing significantly. In gliomas and other
brain tumours, targeted sequencing of cell-free DNA (cfDNA) from CSF may help differential …