As the world endures the coronavirus disease 2019 (COVID-19) pandemic, the conditions of
35 million vulnerable individuals struggling with substance use disorders (SUDs) worldwide …

Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

The use of psychostimulants and alcohol disrupts blood-brain barrier (BBB) integrity,
resulting in alterations to cellular function, and contributes to neurotoxicity. The BBB is the …

Background Methamphetamine (METH) is a commonly abused drug that may result in
neurotoxic effects. Recent studies have suggested that involvement of neuroinflammatory …

The blood brain barrier (BBB) is a highly dynamic interface between the central nervous
system (CNS) and periphery. The BBB is comprised of a number of components and is part …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

In the past two decades a trickle of manuscripts examining the non-neuronal central nervous
system immune consequences of the drugs of abuse has now swollen to a significant body …

During the past two decades, there has been a tremendous expansion of knowledge
regarding the neurobiological effects of substance abuse and how these effects impact …

Pharmacological interventions to treat psychiatric illness have previously focused on
modifying dysfunctional neurotransmitter systems to improve symptoms. However, imperfect …

Rationale and objectives Addiction to psychostimulant methamphetamine (METH) remains a
major public health problem in the world. Animal models that use METH self-administration …