Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of …

Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Purpose: The heterogeneity of high-grade serous ovarian cancer (HGSOC) is not well
studied, which severely hinders clinical treatment of HGSOC. Thus, it is necessary to …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

Because of the high risk of recurrence in high-grade serous ovarian carcinoma (HGS-OvCa),
the development of outcome predictors could be valuable for patient stratification. Using the …

Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently,
one of the challenges is to identify the molecular downstream effects of these variants …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Immune infiltration of colorectal cancer (CRC) is closely associated with clinical outcome.
However, previous work has not accounted for the diversity of functionally distinct cell types …

The inter-differentiation between cell states promotes cancer cell survival under stress and
fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience …

Rapid technical advances in DNA sequencing and genome-wide association studies are
driving the discovery of the germline and somatic mutations that are present in different …