A complex of two related mammalian proteins, SFPQ and NONO, promotes DNA double-
strand break repair via the canonical nonhomologous end joining (c-NHEJ) pathway …

DNA strand breaks can lead to cell carcinogenesis or cell death if not repaired rapidly and
efficiently. An online live cell imaging system was established at the high energy microbeam …

Cellular responses to DNA double-strand breaks (DSBs) not only promote genomic integrity
in healthy tissues, but also largely determine the efficacy of many DNA-damaging cancer …

The study of radiation effects on biological tissues is a diverse field of research with direct
applications to improve human health, in particular in the contexts of radiation therapy and …

In this thesis, manufacturing of microirradiators, electrodeposition of radioactive elements
such as Ni-63, and applications of these radioactive sources are discussed. Ni-63 has a half …

Double-strand break (DSB) repair foci are important therapeutic targets. Here we describe
platforms for delivery of macromolecules, nanomaterials and nanomedicines to repair foci …

Studies of radioactive isotopes at the liquid–solid or gas–solid interface are enabling a
detailed mechanistic understanding of the effects of radioactive decay on physical …

Foci of p53 binding protein 1 (53 BP1) have been used as a biomarker of DNA double-
strand breaks (DSBs) in cells induced by ionizing radiations. 53 BP1 was shown to …

Radiation therapy is used in the treatment of more than 50% of all cancer patients. Despite
immense improvements in the field in the last century, normal tissue toxicity is dose-limiting …

53BP1 is known to be involved in the DNA damage response and has been shown to
localise into discrete foci at the site of DNA double strand breaks (DSBs) after exposure to …