The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

The incidence of chronic pain is high in the general population and it is closely related to
anxiety disorders, which promote negative effects on the quality of life. The cannabinoid …

Chronic neuropathic pain (CNP) is a vast world health problem often associated with the
somatosensory domain. This conceptualization is problematic because, unlike most other …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Depression and anxiety commonly occur in chronic pain states and the coexistence of these
diseases worsens outcomes for both disorders and may reduce treatment adherence and …

The effect of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) on the
dorsolateral prefrontal cortex (DLPFC) can relieve chronic pain and accompanying …

Traumatic brain injury (TBI), a significant contributor to mortality and morbidity worldwide, is
a devastating condition characterized by initial mechanical damage followed by subsequent …

Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

Accumulating evidence suggests hippocampal impairment under the chronic pain
phenotype. However, it is unknown whether neuropathic behaviors are related to …