Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

The coordinated action of cell cycle progression and cell growth (an increase in cell size and
cell mass) is critical for sustained cellular proliferation, yet the biochemical signals that …

Dietary restriction (DR) extends lifespan in multiple species. To examine the mechanisms of
lifespan extension upon DR, we assayed genome-wide translational changes in Drosophila …

The mammalian target of rapamycin (mTOR) has emerged as an important cancer
therapeutic target. Rapamycin and its derivatives that specifically inhibit mTOR are now …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by
extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases …

Genetically engineered mouse models are powerful tools for studying cancer genes and
validating targets for cancer therapy. We previously used a mouse lymphoma model to …

Over the years, studies have focused on the transcriptional regulation of oncogenesis. More
recently, a growing emphasis has been placed on translational control. The Ras and Akt …

Abstract 'They come in all sizes.'Apart from its origin and use in the clothing industry, this
saying reflects the fact that the size of organisms spans an enormous range. Whether …