Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
PROTACs in the management of prostate cancer
P Yedla, AO Babalghith, VV Andra, R Syed - Molecules, 2023 - mdpi.com
Cancer treatments with targeted therapy have gained immense interest due to their low
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …
levels of toxicity and high selectivity. Proteolysis-Targeting Chimeras (PROTACs) have …
Design, synthesis, molecular docking and DFT studies on novel melatonin and isatin based azole derivatives
In order to address the pressing demand for newer broad-spectrum antifungal medicines
with enhanced activity, computer modelling was utilised to rationally develop newer …
with enhanced activity, computer modelling was utilised to rationally develop newer …
4-Adamantyl-(2-(arylidene) hydrazinyl) thiazoles as potential antidiabetic agents: experimental and docking studies
Aim: To develop an efficient and cost-effective antidiabetic agent. Methods: A simple and
convenient Hantzsch synthetic strategy was used to prepare 4-adamantyl-(2-(arylidene) …
convenient Hantzsch synthetic strategy was used to prepare 4-adamantyl-(2-(arylidene) …
Indole–pyridine carbonitriles: multicomponent reaction synthesis and bio-evaluation as potential hits against diabetes mellitus
Background: Diabetes mellitus is a significant health disorder; therefore, researchers should
focus on discovering new drug candidates. Methods: A series of indole–pyridine carbonitrile …
focus on discovering new drug candidates. Methods: A series of indole–pyridine carbonitrile …
Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents
Background: Diabetes mellitus is a serious global health concern, and this is expected to
impact more than 300 million people by 2025. The current study focuses on identifying …
impact more than 300 million people by 2025. The current study focuses on identifying …
Discovery of 5-methylthiazole-thiazolidinone conjugates as potential anti-inflammatory agents: molecular target identification and in silico studies
A series of previously synthesized 5-benzyliden-2-(5-methylthiazole-2-ylimino) thiazoli-din-4-
one were evaluated for their anti-inflammatory activity on the basis of PASS predictive …
one were evaluated for their anti-inflammatory activity on the basis of PASS predictive …
Synthesis of Thiazole‐Chalcone Hybrid Molecules: Antioxidant, Alpha (α)‐Amylase Inhibition and Docking Studies
The molecular hybrid approach is very significant to combat various drug‐resistant
disorders. A simple, convenient, and cost‐effective synthesis of thiazole‐based chalcones is …
disorders. A simple, convenient, and cost‐effective synthesis of thiazole‐based chalcones is …
Thiourea derivatives containing 4-arylthiazoles and d-glucose moiety: design, synthesis, antimicrobial activity evaluation, and molecular docking/dynamics simulations
ND Thanh, PH Lan, HH Anh, NTK Giang… - RSC Medicinal …, 2023 - pubs.rsc.org
Some substituted glucose-conjugated thioureas containing 1, 3-thiazole ring, 4a–h, were
synthesized by the reaction of the corresponding substituted 2-amino-4-phenyl-1, 3 …
synthesized by the reaction of the corresponding substituted 2-amino-4-phenyl-1, 3 …
Discovery of Novel Isatin Encompassing Oxadiazoles as Potential Inhibitors against New Delhi Metallo-β-lactamase-1: Synthesis, Spectral Analysis, Antimicrobial, and …
BT Sridhar, GY Nagesh, K Prashantha… - Russian Journal of …, 2024 - Springer
Objective: Efficient synthesis of isatin Schiff's bases (IIIa–IIId) and isatin-derived 1, 3, 4-
oxadizoles (IVa–IVd) and evaluation of their in vitro antibacterial, antifungal, and anti-TB …
oxadizoles (IVa–IVd) and evaluation of their in vitro antibacterial, antifungal, and anti-TB …