The objective of this article is to present a broad review of the role of cardiac electric rotors
and their accompanying spiral waves in the mechanism of cardiac fibrillation. At the outset …

Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

The development of computational modeling and simulation have immensely benefited the
study of cardiac disease mechanisms and facilitated the optimal disease diagnosis and …

Recent developments in cardiac simulation have rendered the heart the most highly
integrated example of a virtual organ. We are on the brink of a revolution in cardiac …

Recent advances in magnetic resonance (MR) imaging technology have unveiled a wealth
of information regarding cardiac histoanatomical complexity. However, methods to faithfully …

The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

Computational models in physiology often integrate functional and structural information
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …

In the present report, we introduce an integrative three-dimensional electromechanical
model of the left ventricle of the human heart. Electrical activity is represented by the ionic …

Computational models of cardiac electrophysiology have a long history in basic science
applications and device design and evaluation, but have significant potential for clinical …

Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …