Proteins are large, complex molecules responsible for various biological processes.
However, protein misfolding may lead to various life-threatening diseases. Therefore, it is …

Introduction Neurodegeneration is the term describing the death of neurons both in the
central nervous system and periphery. When affecting the central nervous system, it is …

Protein aggregates disrupt cellular homeostasis, causing toxicity linked to
neurodegeneration. Selective autophagic elimination of aggregates is critical to protein …

Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the
substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic …

Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

The manner in which a newly synthesized chain of amino acids transforms itself into a
perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

Abstract Keap1-Nrf2-ARE signaling plays a significant role in protecting cells from
endogenous and exogenous stresses. The development of Nrf2 knockout mice has provided …

The ultimate mechanism that cells use to ensure the quality of intracellular proteins is the
selective destruction of misfolded or damaged polypeptides. In eukaryotic cells, the large …

A range of human degenerative conditions, including Alzheimer's disease, light-chain
amyloidosis and the spongiform encephalopathies, is associated with the deposition in …