Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells
generated during a large array of pathologic conditions ranging from cancer to obesity …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

SARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The
pathogenesis of severe cases remains unknown. We performed an in-depth prospective …

Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Objectives The presence of proinflammatory low-density granulocytes (LDG) has been
demonstrated in autoimmune and infectious diseases. Recently, regulatory neutrophilic …

From the beginning of 2020, an urgent need to understand the pathophysiology of SARS-
CoV-2 disease (COVID-19), much of which is due to dysbalanced immune responses …

Myeloid-derived suppressor cells (MDSCs) were initially identified in humans and mice with
cancer where they profoundly suppress T cell–and NK cell–mediated antitumor immunity …

Chronic immune activation and inflammation are unwanted consequences of many
pathological conditions, since they could lead to tissue damage and immune exhaustion …