I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic
COPD and allergic rhinitis are a global health concern. Despite the coexistence of these …

Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) characterized by a type 2
immune signature often have severe and recurrent disease. Lower airway conditions such …

Background Patients with eosinophilic nasal polyposis frequently require surgery, and
recurrence rates are high. Objective We sought to assess the efficacy and safety of …

The methodology for EPOS2012 has been the same as for the other two productions.
Leaders in the field were invited to critically appraise the literature and write a report on a …

Background The literature regarding clinical olfaction, olfactory loss, and olfactory
dysfunction has expanded rapidly over the past two decades, with an exponential rise in the …

Abstract Purpose of Review The objective of this article is to provide an updated review of
the economic burden of chronic rhinosinusitis (CRS) and discuss how both medical and …

BACKGROUND: There is little scientific evidence to support the current practice of using oral
glucocorticosteroids and antibiotics to treat patients with chronic rhinosinusitis and nasal …

Background: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic 40
inflammatory disease of the nose and paranasal sinuses that is classified according to the …

Background Surgery for chronic rhinosinusitis with nasal polyps (CRSwNPs) often fails
because of recurrence of disease. So far, we do not know if specific cytokine profiles are …