Biomedical research requires both in vitro and in vivo studies in order to explore disease
processes or drug interactions. Foundational investigations have been performed at the …

Three-dimensional tumor models have become established in both basic and clinical
research. As multicellular systems consisting of tumor and tumor-associated cells, they can …

Here, we present a methodology based on multiplexed fluorescence screening of two-or
three-dimensional cell cultures in a newly designed multichambered microwell chip …

Significance: Three-dimensional (3D) visualization of multicellular tumor spheroids (MCTS)
in fluorescence microscopy can rapidly provide qualitative morphological information about …

Background The growth and drug response of tumors are influenced by their stromal
composition, both in vivo and 3D-cell culture models. Cell-type inherent features as well as …

Cell cycle synchronisation is the process of isolating cell populations at specific phases of
the cell cycle from heterogeneous, asynchronous cell cultures. The process has important …

Differences in gene-expression profiles between individual cells can give rise to distinct cell
fate decisions. Yet how localisation on a micropattern impacts initial changes in mRNA …

Serial femtosecond crystallography (SFX) has become one of the standard techniques at X-
ray free-electron lasers (XFELs) to obtain high-resolution structural information from …

Urological malignancy (UM) is among the leading threats to health care worldwide. Recent
years have seen much investment in fundamental UM research, including mechanistic …

Cell fate decisions are ubiquitous and play a critical role throughout development, 14 yet
how localization impacts cellular decision making remains unclear. To identify the drivers 15 …