Cells inherit two centrioles, the older of which is uniquely capable of generating a cilium.
Using proteomics and superresolved imaging, we identify a module that we term DISCO …

Human body temperature limits below 40° C during heat stroke or fever. The implications of
prolonged exposure to the physiologically relevant temperature (40° C) on cellular …

The centrosome executes diverse functions including the nucleation and organization of
microtubules. A subset of centrosomal proteins is found to be involved in regulating the …

Several harmful bacteria have evolved resistance to conventional antibiotics due to their
extensive usage. FtsZ, a principal bacterial cell division protein, is considered as an …

Combretastatin A4 and its analogs are undergoing various clinical trials for the treatment of
different cancers. This study illustrated the molecular mechanism and antitumor activity of …

Tubulin-binding agents are an important class of chemotherapeutic agents. This chapter
describes detailed protocols to examine the effects of tubulin-binding agents on cellular …

Moduli of the extracellular matrix influence multiple cellular functions such as proliferation,
migration, senescence, and differentiation. However, the in vitro studies predominantly …

Centrosomal protein FOR20 has been reported to be crucial for essential cellular processes,
including ciliogenesis, cell migration, and cell cycle in vertebrates. However, the function of …

LMBD1 was previously demonstrated to regulate the endocytosis of insulin receptor on the
cell surface and to mediate the export of cobalamin from the lysosomes to the cytosol, but …