A primer on the analysis of high-throughput sequencing data for detection of plant viruses

D Kutnjak, L Tamisier, I Adams, N Boonham… - Microorganisms, 2021 - mdpi.com
High-throughput sequencing (HTS) technologies have become indispensable tools
assisting plant virus diagnostics and research thanks to their ability to detect any plant virus …

Advances in the field of phage-based therapy with special emphasis on computational resources

N Bajiya, A Dhall, S Aggarwal… - Briefings in …, 2023 - academic.oup.com
In the current era, one of the major challenges is to manage the treatment of drug/antibiotic-
resistant strains of bacteria. Phage therapy, a century-old technique, may serve as an …

Evaluation of computational phage detection tools for metagenomic datasets

KE Schackart III, JB Graham, AJ Ponsero… - Frontiers in …, 2023 - frontiersin.org
Introduction As new computational tools for detecting phage in metagenomes are being
rapidly developed, a critical need has emerged to develop systematic benchmarks. Methods …

Gauge your phage: benchmarking of bacteriophage identification tools in metagenomic sequencing data

SFS Ho, NE Wheeler, AD Millard, W van Schaik - Microbiome, 2023 - Springer
Background The prediction of bacteriophage sequences in metagenomic datasets has
become a topic of considerable interest, leading to the development of many novel …

RNN-VirSeeker: a deep learning method for identification of short viral sequences from metagenomes

F Liu, Y Miao, Y Liu, T Hou - IEEE/ACM Transactions on …, 2020 - ieeexplore.ieee.org
Viruses are the most abundant biological entities on earth, and play vital roles in many
aspects of microbial communities. As major human pathogens, viruses have caused huge …

[HTML][HTML] Large language models improve annotation of viral proteins

ZN Flamholz, SJ Biller, L Kelly - Research square, 2023 - ncbi.nlm.nih.gov
Viral sequences are poorly annotated in environmental samples, a major roadblock to
understanding how viruses influence microbial community structure. Current annotation …

What the Phage: a scalable workflow for the identification and analysis of phage sequences

M Marquet, M Hölzer, MW Pletz, A Viehweger… - …, 2022 - academic.oup.com
Phages are among the most abundant and diverse biological entities on earth. Phage
prediction from sequence data is a crucial first step to understanding their impact on the …

Benchmarking informatics approaches for virus discovery: caution is needed when combining in silico identification methods

B Hegarty, J Riddell V, E Bastien, K Langenfeld… - Msystems, 2024 - Am Soc Microbiol
Understanding the ecological impacts of viruses on natural and engineered ecosystems
relies on the accurate identification of viral sequences from community sequencing data. To …

VirHunter: A deep learning-based method for detection of novel RNA viruses in plant sequencing data

G Sukhorukov, M Khalili, O Gascuel… - Frontiers in …, 2022 - frontiersin.org
High-throughput sequencing has provided the capacity of broad virus detection for both
known and unknown viruses in a variety of hosts and habitats. It has been successfully …

Hecatomb: an integrated software platform for viral metagenomics

MJ Roach, SJ Beecroft, KA Mihindukulasuriya… - …, 2024 - academic.oup.com
Background Modern sequencing technologies offer extraordinary opportunities for virus
discovery and virome analysis. Annotation of viral sequences from metagenomic data …