A large number of diverse mechanisms that lead to cytoprotection have been described to
date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In …

Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad
anticancer potential, its clinical use has regularly been constrained by kidney toxicities. This …

(1) Background: Cancer is one of the leading causes of mortality worldwide. Radiotherapy
and chemotherapy attempt to kill tumor cells by different mechanisms mediated by an …

Platinum-based anticancer drugs (PADs), mainly cisplatin, carboplatin, and oxaliplatin, are
widely used efficacious long-standing anticancer agents for treating several cancer types …

This study investigated the ameliorative potential of methanolic date flesh extract (MDFE)
against cisplatin-induced hepatic injury. Twenty male rats (weighing 180–200 g) were …

Background Considerable controversies exist regarding the severity of skeletal muscle
wasting (SMW) during neoadjuvant therapy (NAT) and its impact on therapeutic outcomes in …

Background and purpose: Cisplatin-induced nephrotoxicity (CisIN) remains the most dose-
limiting adverse effect of its clinical use. The protective effects of melatonin on CisIN have …

Despite cisplatin has been widely used in the treatment of various cancers, the noteworthy
nephrotoxicity greatly constrained its clinical value. For this reason, finding novel targeted …

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most detrimental toxicity
to a patient's quality of life. Pathophysiological mechanisms involved in CIPN pathogenesis …

Purpose: Cisplatin (CIS) is a platinum based anticancer drug that has demonstrated
significant efficacy against various types of cancers. Unfortunately, this drug is also famous …