Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

The epithelial Na+ channel (ENaC) is a pathway for Na+ transport across epithelia,
including the kidney collecting duct, lung, and distal colon. ENaC is critical for Na+ …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

The vasopressin type 2 receptor (V2R) is a critical G protein-coupled receptor (GPCR) for
vertebrate physiology, including the balance of water and sodium ions. It is unclear how its …

Epithelial sodium channels (ENaC) are expressed in the apical membrane of high
resistance Na+ transporting epithelia and have a key role in regulating extracellular fluid …

Chemical modulation of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACi) is
an increasingly important approach for modifying the etiology of human disease. Loss-of …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

In renal epithelia, vasopressin influences salt and water transport, chiefly via vasopressin V2
receptors (V2Rs) linked to adenylyl cyclase. A combination of vasopressin-induced effects …

Sepsis-associated acute renal failure is characterized by decreased GFR and tubular
dysfunction. The pathogenesis of endotoxemic tubular dysfunction with failure in urine …