Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

The need to develop new tools and increase capacity to test pharmaceuticals and other
chemicals for potential adverse impacts on human health and the environment is an active …

After multiple drugs were removed from the market secondary to drug‐induced torsade de
pointes (TdP) risk, the International Council for Harmonisation (ICH) released guidelines in …

Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …

Current gaps in drug safety sciences can result from the inability (1) to identify hazard across
multiple target organs,(2) to predict and risk assess with certainty against drug safety …

Defining an appropriate and efficient assessment of drug‐induced corrected QT interval
(QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a …

Cardiac arrhythmias are a major cause of death and disability. A large number of
experimental cell and animal models have been developed to study arrhythmogenic …

High-throughput in vitro drug assays have been impacted by recent advances in human
induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology and by contact …

Rationale: Drug-induced proarrhythmia is so tightly associated with prolongation of the QT
interval that QT prolongation is an accepted surrogate marker for arrhythmia. But QT interval …