Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality
rate continues to be unacceptably high. The biomarkers currently used in clinical practice …

A host of novel renal biomarkers have been developed over the past few decades which
have enhanced monitoring of renal disease and drug-induced kidney injury in both …

Background Chronic kidney disease (CKD) leads to end-stage renal failure and
cardiovascular events. An attribute to these progressions is abnormalities in inflammation …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Acute and chronic kidney disease continues to confer significant morbidity and mortality in
the clinical setting. Despite high prevalence of these conditions, few validated biomarkers …

Context Baicalin, a flavonoid extracted from radix scutellariae, possesses various
pharmacological effects, including protective effects on renal interstitial fibrosis (RIF), but its …

Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary
protein in healthy individuals. Over the years, studies have revealed compelling …

Hypertension is a significant risk factor for cardiovascular disease and mortality worldwide.
The kidney is a major regulator of blood pressure and electrolyte homeostasis, with …