Engineering an optimal Y280-lineage H9N2 vaccine strain by tuning PB2 activity

SH An, SM Hong, JH Song, SE Son, CY Lee… - International Journal of …, 2023 - mdpi.com
H9N2 avian influenza A viruses (AIVs) cause economic losses in the poultry industry and
provide internal genomic segments for the evolution of H5N1 and H7N9 AIVs into more …

Bioengineering a highly productive vaccine strain in embryonated chicken eggs and mammals from a non-pathogenic clade 2· 3· 4· 4 H5N8 strain

SH An, CY Lee, SM Hong, JG Choi, YJ Lee, JH Jeong… - Vaccine, 2019 - Elsevier
Abstract The clade 2· 3· 4· 4 H5Nx is a highly pathogenic avian influenza (HPAI) virus, which
first appeared in China and has spread worldwide since then, including Korea. It is divided …

[HTML][HTML] A Model H5N2 Vaccine Strain for Dual Protection Against H5N1 and H9N2 Avian Influenza Viruses

JH Song, SE Son, HW Kim, SH An, CY Lee, HJ Kwon… - Vaccines, 2024 - mdpi.com
Background/Objective: Highly pathogenic (HP) H5Nx and low-pathogenicity (LP) H9N2
avian influenza viruses (AIVs) pose global threats to the poultry industry and public health …

Selection of an optimal recombinant egyptian H9N2 avian influenza vaccine strain for poultry with high antigenicity and safety

SH An, SE Son, JH Song, SM Hong, CY Lee, NH Lee… - Vaccines, 2022 - mdpi.com
For the development of an optimized Egyptian H9N2 vaccine candidate virus for poultry,
various recombinant Egyptian H9N2 viruses generated by a PR8-based reverse genetics …

Protective efficacy of a bivalent H5 influenza vaccine candidate against both clades 2.3. 2.1 and 2.3. 4.4 high pathogenic avian influenza viruses in SPF chickens

H Kim, HK Cho, YM Kang, M Sagong, S An, S Kim… - Vaccine, 2023 - Elsevier
Worldwide, high pathogenic avian influenza viruses belonging to clades 2.3. 4.4 and 2.3. 2.1
have been circulating in both poultry and wild birds. Since 2018, Korea has built a national …

Generation of highly productive and mammalian nonpathogenic recombinant H9N2 avian influenza viruses by optimization of 3'end promoter and NS genome

SH An, CY Lee, JG Choi, YJ Lee, JH Kim… - Veterinary microbiology, 2019 - Elsevier
Abstract We developed A/PR/8/34 (PR8) virus-based reverse genetics system in which six
internal genes of PR8 and attenuated hemagglutinin and intact neuraminidase genes of …

Improvement of PR8-derived recombinant clade 2.3. 4.4 c H5N6 vaccine strains by optimization of internal genes and H103Y mutation of hemagglutinin

SH An, SM Hong, SE Son, JH Song, CY Lee, JG Choi… - Vaccines, 2020 - mdpi.com
Clade 2.3. 4.4 c H5N6 avian influenza A viruses (AIVs) may have originally adapted to infect
chickens and have caused highly pathogenic avian influenza (HPAI) in poultry and human …

Novel mutations evading avian immunity around the receptor binding site of the clade 2.3. 2.1 c hemagglutinin gene reduce viral thermostability and mammalian …

SH An, CY Lee, SM Hong, CS Song, JH Kim, HJ Kwon - Viruses, 2019 - mdpi.com
Since 2007, highly pathogenic clade 2.3. 2 H5N1 avian influenza A (A (H5N1)) viruses have
evolved to clade 2.3. 2.1 a, b, and c; currently only 2.3. 2.1 c A (H5N1) viruses circulate in …

[PDF][PDF] ĐÁNH GIÁ TÌNH HÌNH LƯU HÀNH VI-RÚT CÚM GIA CẦM TẠI KHU VỰC LÂN CẬN THÀNH PHỐ HỒ CHÍ MINH VÀ KHẢ NĂNG BẢO HỘ CỦA VẮC-XIN NAVET …

T TP - pgo.hcmuaf.edu.vn
TÓM TẮT Đề tài “Đánh giá tình hình lưu hành vi-rút Cúm gia cầm tại khu vực lân cận Thành
phố Hồ Chí Minh và khả năng bảo hộ của vắc-xin Navet-Fluvac 2 đối với vi-rút Cúm gia cầm …

H5N6 recombinant influenza virus, a composition for preparing the same, and a vaccine composition containing the same

HJ Kwon, SH An, SM Hong - US Patent 12,090,199, 2024 - Google Patents
The present invention relates to an mammalian non-pathogenic, highly-productive-in-
embryonated-egg, heat-resistant, and attenuated clade 2.3. 4.4 c H5N6 recombinant …