Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics
in the heart. Whereas mechanical activity is usually seen as 'the endpoint'of cardiac auto …

Background Heart failure (HF) has been recognized as a global pandemic with a high rate of
hospitalization, morbidity, and mortality. Although numerous advances have been made, its …

Background: Heart failure (HF) is characterized by electrophysiological remodeling resulting
in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic …

Introduction: Despite a burgeoning knowledge of the intricacies and mechanisms
responsible for human disease, technological advances in medicinal chemistry, and more …

Abnormal intracellular Ca2+ handling is the major contributor to the depressed cardiac
contractility observed in heart failure. The electrophysiological remodeling associated with …

Two-pore K+ (K2p) channels have been described in modulating background conductance
as leak channels in different physiological systems. In the heart, the expression of K2p …

Heart failure is a leading cause of death, yet its underlying electrophysiological (EP)
mechanisms are not well understood. In this study, we use a multiscale approach to analyze …

Objective: The pathophysiological role of the small conductance calcium-activated
potassium (SK) channels in human ventricular myocytes remains unclear. Experimental …

Computational models of the cardiovascular system and specifically heart function are
currently being investigated as analytic tools to assist medical practice and clinical trials. To …

The sinoatrial node (SAN), the pacemaker of the mammalian heart, possesses intrinsic
automaticity. Dysfunction of the SAN may lead to abnormal cardiac rhythms, manifested by …