Reprogramming of Treg cells in the inflammatory microenvironment during immunotherapy: a literature review

X Wu, Z Zhou, Q Cao, Y Chen, J Gong… - Frontiers in …, 2023 - frontiersin.org
Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in
the research of tumor progression. Treg cells have the function of inhibiting the immune …

Innovative breakthroughs facilitated by single-cell multi-omics: manipulating natural killer cell functionality correlates with a novel subcategory of melanoma cells

Z Zhao, Y Ding, LJ Tran, G Chai, L Lin - Frontiers in immunology, 2023 - frontiersin.org
Background Melanoma is typically regarded as the most dangerous form of skin cancer.
Although surgical removal of in situ lesions can be used to effectively treat metastatic …

Exploiting gender-based biomarkers and drug targets: advancing personalized therapeutic strategies in hepatocellular carcinoma

L Su, H Luo, Y Yan, Z Yang, J Lu, D Xu, L Du… - Frontiers in …, 2024 - frontiersin.org
This review systematically examines gender differences in hepatocellular carcinoma (HCC),
identifying the influence of sex hormones, genetic variance, and environmental factors on …

Integrating multiple machine learning methods to construct glutamine metabolism-related signatures in lung adenocarcinoma

P Zhang, S Pei, L Wu, Z Xia, Q Wang… - Frontiers in …, 2023 - frontiersin.org
Background Glutamine metabolism (GM) is known to play a critical role in cancer
development, including in lung adenocarcinoma (LUAD), although the exact contribution of …

FAM family gene prediction model reveals heterogeneity, stemness and immune microenvironment of UCEC

H Chi, X Gao, Z Xia, W Yu, X Yin, Y Pan… - Frontiers in Molecular …, 2023 - frontiersin.org
Background: Endometrial cancer (UCEC) is a highly heterogeneous gynecologic
malignancy that exhibits variable prognostic outcomes and responses to immunotherapy …

Molecular characteristics and therapeutic implications of Toll-like receptor signaling pathway in melanoma

H Guan, X Chen, J Liu, J Sun, H Guo, Y Jiang… - Scientific Reports, 2023 - nature.com
Melanoma is a malignant tumor of melanocytes and is often considered immunogenic
cancer. Toll-like receptor-related genes are expressed differently in most types of cancer …

A novel signature predicts prognosis and immunotherapy in lung adenocarcinoma based on cancer-associated fibroblasts

Q Ren, P Zhang, H Lin, Y Feng, H Chi… - Frontiers in …, 2023 - frontiersin.org
Background Extensive research has established the significant correlations between cancer-
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …

Integrated multi-omics identified the novel intratumor microbiome-derived subtypes and signature to predict the outcome, tumor microenvironment heterogeneity, and …

B Zhang, J Liu, H Li, B Huang, B Zhang… - Frontiers in …, 2023 - frontiersin.org
Background: The extremely malignant tumour known as pancreatic cancer (PC) lacks
efficient prognostic markers and treatment strategies. The microbiome is crucial to how …

A novel T-cell exhaustion-related feature can accurately predict the prognosis of OC patients

K Yuan, S Zhao, B Ye, Q Wang, Y Liu… - Frontiers in …, 2023 - frontiersin.org
The phenomenon of T Cell exhaustion (TEX) entails a progressive deterioration in the
functionality of T cells within the immune system during prolonged conflicts with chronic …

Revealing the role of regulatory T cells in the tumor microenvironment of lung adenocarcinoma: a novel prognostic and immunotherapeutic signature

P Zhang, X Zhang, Y Cui, Z Gong, W Wang… - Frontiers in …, 2023 - frontiersin.org
Background Regulatory T cells (Tregs), are a key class of cell types in the immune system. In
the tumor microenvironment (TME), the presence of Tregs has important implications for …