Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
[PDF][PDF] Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery
Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …
modeling and have unlocked new possibilities for understanding the mechanisms governing …
[PDF][PDF] Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
[PDF][PDF] Cardioids reveal self-organizing principles of human cardiogenesis
P Hofbauer, SM Jahnel, N Papai, M Giesshammer… - Cell, 2021 - cell.com
Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …
human development and disease. With the notable exception of the human heart, lineage …
Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity
DJ Richards, Y Li, CM Kerr, J Yao, GC Beeson… - Nature biomedical …, 2020 - nature.com
Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …
[PDF][PDF] A platform for generation of chamber-specific cardiac tissues and disease modeling
Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds a
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …
Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations
A Fomin, A Gärtner, L Cyganek, M Tiburcy… - Science translational …, 2021 - science.org
Heterozygous truncating variants in TTN (TTNtv), the gene coding for titin, cause dilated
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …
cardiomyopathy (DCM), but the underlying pathomechanisms are unclear and disease …
Large cardiac muscle patches engineered from human induced-pluripotent stem cell–derived cardiac cells improve recovery from myocardial infarction in swine
Background: Here, we generated human cardiac muscle patches (hCMPs) of clinically
relevant dimensions (4 cm× 2 cm× 1.25 mm) by suspending cardiomyocytes, smooth muscle …
relevant dimensions (4 cm× 2 cm× 1.25 mm) by suspending cardiomyocytes, smooth muscle …
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …
functional requirements of an adult. However, the key drivers of this process remain poorly …
[HTML][HTML] Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
IY Shadrin, BW Allen, Y Qian, CP Jackman… - Nature …, 2017 - nature.com
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …