The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

The Transforming Growth Factor-beta (TGF-β) family plays relevant roles in the regulation of
different cellular processes that are essential for tissue and organ homeostasis. In the case …

Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart
failure, but it remains elusive whether there is a common pathway to induce both events …

The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Cancer-associated muscle weakness is a poorly understood phenomenon, and there is no
effective treatment. Here we find that seven different mouse models of human osteolytic …

Liver fibrosis is a regenerative process that occurs after injury. It is characterized by the
deposition of connective tissue by specialized fibroblasts and concomitant proliferative …

Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

Age-related diseases such as obesity, diabetes, non-alcoholic fatty liver disease, chronic
kidney disease and cardiomyopathy are frequently associated with fibrosis. Work within the …