RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …

DNA repair pathways can enable tumour cells to survive DNA damage that is induced by
chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might …

DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …

Signaling pathways that respond to DNA damage are essential for the maintenance of
genome stability and are linked to many diseases, including cancer. Here, a genome-wide …

Recent findings suggest important roles for nuclear organization in gene expression. In
contrast, little is known about how nuclear organization contributes to genome stability …

Understanding the role of DNA damage checkpoint kinases in the cellular response to
genotoxic stress requires the knowledge of their substrates. Here, we report the use of …

Non-random positioning of chromosomal domains relative to each other and to nuclear
landmarks is a common feature of eukaryotic genomes. In particular, the distribution of DNA …

Transcription hinders replication fork progression and stability, and the Mec1/ATR
checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling …

Persistent DNA double-strand breaks (DSBs) are recruited to the nuclear periphery in
budding yeast. Both the Nup84 pore subcomplex and Mps3, an inner nuclear membrane …

Nuclear pore complexes (NPCs) are composed of several copies of∼ 30 different proteins
called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the …